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1·She will be a great loss to the school.

她这一走对学校来说将是一个巨大的损失。《牛津词典》

2·She said his death was a great loss to herself.

她说他的去世对于她来说是个巨大的损失。《柯林斯英汉双解大词典》

3·He has sustained a great loss by the death of his father.

他父亲的去世使他蒙受巨大的损失。《新英汉大辞典》

4·The Old Summer Palace was burned to the ground, which is a great loss in human history.

圆明园被焚烧近尽，这是人类历史上的一大笔损失。

5·The author claims that it will be a great loss if we no longer read books and longer articles.

作者声称，如果我们不再阅读书籍和更长的文章，这将是一个巨大的损失。

6·The company will suffer a great loss on the condition that it is forbidden to exploit this kind of alternative resource.

如果公司被禁止开发这种替代资源，公司将蒙受巨大损失。

7·His death is a great loss to his country.

他的逝世是国家的重大损失。《新英汉大辞典》

8·What a great loss to our nation!

对我们国家是多么大的损失啊！

9·His death is a great loss to us.

他的死是我们的巨大损失。

10·His resign was a great loss to us.

他的辞职对我们是个巨大损失。