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1·Histone lysine methylation plays a key role in epigenetic regulation of eukaryotic genes.

组蛋白赖氨酸的甲基化在真核基因表观遗传调控中起着关键作用。

2·These modifications regulate histone-DNA interactions, adding a new dimension to the epigenetic regulation of nucleosome mobility.

这些修饰调控组蛋白- DNA相互作用，为核小体迁移的表观遗传调控添加了新的维度。

3·The methylation of histone lysine is an important covalent modification at its tails and plays a key role in epigenetic regulation.

组蛋白赖氨酸甲基化是组蛋白尾段发生的一种重要共价修饰，在基因的表观遗传转录调控中起着关键的作用。

4·At the same time, more and more studies have suggested that epigenetic regulation may play important roles in cancer stem cell development.

与此同时，越来越多的研究表明，对于肿瘤干细胞的发生与功能维持，表观遗传学的调控机制可能发挥着极其重要的作用。

5·Here we've established a new role for SUMOylation, mediating the interaction between protein and protein methylation in epigenetic regulation.

在这里我们已经建立了SUMO结合的新角色，在表观遗传调控中调控的蛋白质和蛋白质甲基化。

6·In the present paper we review the role and molecular mechanism of transcription factors, epigenetic regulation and cell signaling in cell reprogramming.

本文主要从转录因子、表观遗传和信号转导等角度，介绍了细胞重编程分子机制研究方面的进展和未来的方向。

7·Using yeast as model organism, study the contribution of epigenetic regulation to the maintenance of genomic stability, by epigenetic, molecular genetic and biochemic approaches.

以酵母为模式生物，利用表观遗传，分子遗传和生物化学等手段，研究表观遗传调控在维持基因组稳定性中的作用。

8·These findings improve the understanding of epigenetic regulation of HBV transcription and host-HBV interaction, thus provide new insights into targeted therapeutic intervention.

这些发现改善了对HBV转录和宿主- HBV相互作用的表观遗传调节的理解，因此提供了对靶向治疗干预的新见解。

9·These results extend the landscape of genetic alterations in leukaemia, and identify mutations targeting transcriptional and epigenetic regulation as a mechanism of resistance in ALL.

这些结果扩展了白血病的基因变异谱，确定后天调控与转录靶向突变为ALL的耐药机制。

10·The 2007 pilot results were eye-opening: Chromosomes harbored many previously unsuspected sites where various proteins bound—possible hotbeds of gene regulation or epigenetic effects.

2007年的试验结果令人眼界大开：染色体上藏着许多以前不为人知的位点，那里结合着各种各样的蛋白——可能是基因调控和表观遗传效应的温床。