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1·Application of excessive hours can cause metabolic alkalosis.

应用过量时，可致代谢性碱中毒。

2·Clearly, this kind of metabolic alkalosis would not respond to saline infusion.

显然，这种代谢性碱中毒对盐水输入没有反应。

3·High doses of frusemide are associated with severe electrolyte disturbance and metabolic alkalosis, and should be used cautiously.

大剂量的速尿会引起严重电解质紊乱和代谢性碱中毒，应该慎重使用。