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1·The results show that the stable leu2 mutants have been constructed successfully by one-step gene disruption.

结果表明，用一步基因中断法成功地建立了稳定的LEU2基因突变体。

2·Most importantly, such a precise gene disruption in the nervous system will allow us to study specific roles of candidate genes in neurodegenerative diseases that afflict the aging.

更为重要的可能在于，在神经系统中有目的干扰某个基因的表达，对影响寿命的有关神经退行性疾病的研究将会有所助益。

3·It is marked by a mutation in a gene known as RPE65 which results in a missing enzyme that leads to degradation of the retina and the disruption of vision processing in the brain.

这种病的特点是，一段名为RPE65的基因发生变异，导致缺失，进而引起视网膜退化，大脑视觉处理中断。

4·Intronic mutations may affect gene regulation through aberrant splicing or disruption of critical DNA protein interactions.

内含子突变可以通过引起剪接异常或关键性DNA -蛋白反应中断而影响基因调控。

5·Targeted disruption of the murine Nkx2.5 gene results in abnormal heart morphogenesis, severe growth retardation, and embryonic lethality around E9.5 (1, 2).

靶向缺失小鼠nkx2.5基因会导致心脏形态异常，严重的发育迟缓以及E9.5胚胎致死(1,2)。

6·The database contains the information on disruption phenotypes, gene expression, and protein localization on a genome-wide scale in Saccharomyces.

数据库中包括转座以后表型的改变， 基因表达和酵母 基因组水平蛋白的定位等数据。