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1·Histone acetylation contributes to expression of gene, while histone deacetylation leads to repression of gene expression.

组蛋白乙酰化促进基因表达，而去乙酰化则抑制基因表达。

2·Conclusion APP expression on SH-SY5Y cells may increase through up-regulation of histone acetylation through P38MAPK pathway.

结论P 38 MAPK信号通路可能通过上调组蛋白乙酰化水平增加SH - SY5Y的APP蛋白表达。

3·Histone acetylation and deacetylation can regulate many chromosome functions, such as gene expression and chromosome segregation.

组蛋白乙酰化和去乙酰化可调节染色体的多种功能，例如基因表达和染色体分离等。

4·As in the Alzheimer's mice, drugs that boosted histone acetylation improved the older mice's performance on tests of rodent cognition.

如同阿尔茨海默病鼠，增强组蛋白乙酰化的药物改善了年老小鼠在认知测试中的表现。

5·Histone acetylation and de-acetylation can change the structure of chromatin, involving in gene expression regulation and nuclear reprogramming.

组蛋白乙酰化和去乙酰化可以改变染色质的结构，参与基因的表达调控和重编程。

6·Histone acetylation has a close relation with some biological effects such as gene transcription, and is catalyzed by histone acetyltransferases.

组蛋白乙酰化与基因转录等生物效应有密切的关系，组蛋白乙酰化主要是由组蛋白乙酸转移酶催化的。

7·Other work has focused on histone acetylation, a chemical modification that unwinds DNA from protein spools called histones, thereby enabling gene activity.

其他的工作集中在组蛋白乙酰化，这种化学修饰可以使DNA从组蛋白缠绕中解离出来，产生基因活性。

8·Combined with the results of histone deactylase inhibitor, it is suggested that histone acetylation plays an important role in hsp gene transcription regulation.

结合以上去乙酞化酶抑制剂的实验结果，我们认为组蛋白乙酞化修饰参与了热休克基因的表达调控。

9·In the 10 May 2007 issue of Nature, they reported that a drug that promotes histone acetylation improved learning and memory in a mouse model of Alzheimer's disease.

在2007年5月10日的自然杂志中，他们报道了一种促进组蛋白乙酰化的药物，它能增强阿耳茨海默氏病模型老鼠的学习和记忆能力。

10·Purpose to investigate the effects of DNA methylation and histone acetylation on the expression of tumor associated genes and cell cycle progression in human colonic cancer cells.

目的观察dna甲基化和组蛋白乙酰化对人结肠癌细胞系癌相关基因的表达和细胞周期的影响。