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1·Objective To study the effects E. coli purine nucleoside phosphorylase suicide gene on human gastric cancer MKN-45 cells as well as the bystander effect.

目的：探讨大肠杆菌嘌呤核苷磷酸化酶自杀基因对胃癌细胞MKN-45的抑制及杀伤作用，并证实旁观者效应。

2·Conclusions the double suicide gene driven by KDR promoter has specific killing effect on KDR-expressing gastric tumor cells and venous endothelial cells in vitro.

结论K DR基因启动子可调控双自杀基因系统选择性杀伤表达KDR胃癌细胞及血管内皮细胞。

3·Objective To construct a new retroviral vector with double-suicide genes and knockout-inducible SV40T gene, with the aim of optimizing immortalization of hepatocytes.

目的构建携带双自杀基因且可诱导敲除SV40T的逆转录病毒载体，优化目前的肝细胞永生化。

4·Objective To determine the efficacy of adenovirus-mediated suicide gene transduction combined with prodrug 5-fluorocytosine (5FC) as a therapeutic protocol for pancreatic cancer.

目的探讨腺病毒介导自杀基因联合前药5FC对人胰腺癌的治疗作用。

5·Results Double and single suicide gene transfer were both stably expressed in GLC-82 cells. The cytotoxic effects of co-expressed TK-CD genes were superior than that of the single gene.

结果单、双自杀基因均在GLC - 82细胞中稳定表达，双基因转染组对细胞增殖的杀伤及旁杀伤效应高于单基因组。

6·Our results demonstrated that combined transfer of suicide gene and IL-2 gene could inhibit the growth of established tumor in mice significantly and induce antitumor immunity of the host efficiently.

实验结果表明，联合应用自杀基因与细胞因子基因治疗可更有效诱导机体的抗肿瘤免疫反应，从而更显著地抑制荷瘤小鼠肿瘤的生长。

7·In recent years, it has also become clear that carriers of a particular version of a particular gene are at higher risk than others of depression and attempted suicide when they face traumatic events.

近年来越来越清楚的是，具有某种特定基因的特定版本的人们，会比其他沮丧基因版本的人承受更大的风险，而且遭遇心理创伤时会尝试自杀。

8·Objective The purpose of the study was to investigate the association of A1438G polymorphism of 5 -HT2A receptor gene with attempted suicide in psychiatric patients.

目的探讨五-羟色胺2A（5-HT2A）受体基因A1438G多态性与精神疾病患者的自杀未遂之间的关系。