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1·He has known great misfortune in his life.

他一生中经历过巨大的不幸。《牛津词典》

2·A great misfortune befell him.

一场大难降临到他的头上。

3·She said it was a great misfortune.

她说，这真是天大的不幸。

4·Great fortune brings with it great misfortune.

大福总伴随着大祸。

5·This too is meaningless and a great misfortune.

这真是虚空和大不幸。

6·Great good-nature, without prudence, is a great misfortune.

善良的个性若不知谨慎，将是大大的不幸。

7·Then a great misfortune crept over the town and everything began to change.

后来，厄运降临到这座城镇，一切都开始发生变化。

8·Beauty is universally treasured, yet beauty might also bring great misfortune.

美为全世界人所珍视，但是，美也可能带来厄运。

9·It has been the great misfortune of our Alsace always to postpone its lessons until tomorrow.

我们阿尔萨斯人的最大不幸就是把教育拖延到明天。

10·In short, it tells the story about how Helen Keller faces her life after she suffers great misfortune.

简而言之，这本书说的是海伦·凯勒在她遭受强大的不幸后她如何地面对生活。