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1·What's up? I said to him.—Just tired, he answered.

“出了什么事？”我对他说。— “只是累了，”他答道。《柯林斯英汉双解大词典》

2·What's up with you, chuck?

你怎么了，亲爱的？《牛津词典》

3·What's up with him? He looks furious.

他怎么了？他看上去怒气冲冲。《牛津词典》

4·Hey, dude, what's up?

喂，哥们儿，怎么啦？《牛津词典》

5·What's up?

怎么了？

6·I'm at home. What's up?

我在家。怎么了？

7·You look a little unhappy. What's up?

你看起来有点不开心。怎么了？

8·What's up with the mime act?

哑剧表演是怎么回事？

9·What's up? What is this car for?

出什么事了？这车是干嘛的？

10·What's up? Wait a minute, please.

怎么了？请等一下。