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1·ATM kinase regulates a number of proteins involved in cell cycle checkpoint control, apoptosis, and DNA repair.

AT M激酶调节许多蛋白，涉及细胞周期检验点的控制、细胞凋亡和DNA修复。

2·To maintain genomic integrity, cells have evolved complex surveillance mechanisms termed cell cycle checkpoint.

为确保遗传准确性，细胞形成了复杂的细胞周期监督机制，即细胞周期检验点。

3·Several factors, such as defects in chromosome segregation and DNA damage response, failure of cell cycle checkpoint, telomere dysfunction, may cause chromosomal instability.

多种细胞机制功能障碍将导致染色体不稳定性，包括染色体分离、DNA损伤反应、细胞周期检查点、端粒功能等。

4·To ensure genome integrity and prevent aneuploidy, eukaryotes have evolved an integrated protective mechanism, including cell cycle control, checkpoint control, and DNA repair.

真核生物对维持基因组的稳定性及防止非整倍体的产生，有其一套完整的保护机制，即细胞周期调控、检验点调控以及对损伤DNA的修复。

5·An important part of the cellular response to DNA damage is checkpoint activation - checkpoint kinases CHK1 and CHK2 phosphorylate key proteins to elicit cell-cycle blocks.

细胞对DNA损伤作出应答的一个重要过程是检查点活化(检查点激酶CHK1和CHK2使关键蛋白磷酸化，从而阻止正常的细胞周期。)

6·The checkpoint regulation of budding yeast cell cycle was introduced in this paper.

就芽殖酵母细胞周期检查点调控加以介绍。

7·Chk1 exerts its checkpoint mechanism on the cell cycle, in part, by regulating the cdc25 family of phosphatases.

Chk1发挥其细胞周期检验点调节机制部分经由调控磷酸酶家族的cdc25。

8·Highly conserved DNA-repair and cell-cycle checkpoint pathways allow cells to deal with both endogenous and exogenous sources of DNA damage.

高度保守的DNA修复和细胞周期检查点通路使得细胞能够应付各种内源性或外源性因素引起的DNA损伤。