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1·Chronic kidney disease is subject to the double impact of genetic and epigenetic modification.

慢性肾脏疾病受到遗传因素和表观遗传修饰的双重影响。

2·DNA methylation is an important epigenetic modification which regulates a number of biological processes.

DNA甲基化作为一种重要的表观遗传修饰，调节着机体许多生物学过程。

3·Objective: With the research of tumor developing mechanism, epigenetic modification has become a new view.

目的：随着对肿瘤发生机制研究的不断深入，表观遗传修饰成为新的研究热点。

4·DNA methylation is a major epigenetic modification and plays a crucial role in embryonic development and placentas 'development.

DNA甲基化是一种主要的表观遗传修饰，对于胚胎发育、胎盘及胎儿的生长具有重要作用。

5·Methylation is an epigenetic modification to one's DNA that changes a gene's activity, generally reducing that activity within the genome.

甲基化作用是对DNA的后天修改，并改变基因活动，通常是在基因组内减少这个活动。

6·The discovery of the histone lysine demethylases has strongly demonstrated that histone lysine methylation is a reversible epigenetic modification.

随着组蛋白赖氨酸去甲基化酶的发现，证实组蛋白赖氨酸甲基化是一个可以逆转的组蛋白表遗传修饰。

7·The donor nucleus must experienced the epigenetic modification of the process reprogramming and went back to the initial state after the donor cell was injected into the oocytes.

供体细胞核移入去核的卵母细胞后，必定要经过表观遗传修饰的重编程过程，回到胚胎开始发育的全能状态。

8·Epigenetic mechanisms, including DNA methylation, histone modification and chromatin remodeling, have been demonstrated to be involved in the development of SLE.

表观遗传学涉及的机制主要包括DNA甲基化和组蛋白修饰及染色质重塑。

9·Core processes of epigenetic inheritance include DNA methylation, histone modification, nucleosome remodeling, nuclear dynamics and chromatin interaction with non-coding RNAs.

核心过程的表观遗传的产业包括DNA甲基化、组蛋白改性、核小体重建、核染色质动力学和互动子都存在。

10·The methylation of histone lysine is an important covalent modification at its tails and plays a key role in epigenetic regulation.

组蛋白赖氨酸甲基化是组蛋白尾段发生的一种重要共价修饰，在基因的表观遗传转录调控中起着关键的作用。