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1·ACO2 is also an important regulator of iron homeostasis within cells (1-4).

ACO2也是细胞内铁稳态的重要调节因子(1 - 4)。

2·AIM To explore whether there is relationship between iron homeostasis disorder and neurodegeneration induced by aluminum (al) overload.

目的探讨铝致神经元退行性变是否与脑铁代谢失衡有关。

3·There were obvious expression alterations in the genes involved in ion homeostasis especially in iron and copper.

与金属离子平衡，特别是与铁离子和铜离子平衡有关的基因表达有较大变化。

4·CONCLUSION: Nimodipine relieves the neurodegeneration induced by aluminum overload through inhibiting the expression of HO-1 and keeping the homeostasis of iron.

结论：尼莫地平可能通过抑制HO - 1表达、维持铁离子稳态，减轻铝过负荷所致的神经元退行性变。