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1·Objective: To investigate the anti-tumor mechanism of hirudin.

目的：探讨复方水蛭素抗肿瘤的作用机理。

2·PurposeThe aim is to obtain recombinant hirudin gene using PCR method.

目的应用PCR方法获得水蛭素基因。

3·The anticoagulation effect of hirudin was better than dipyridamole (P<0.01).

水蛭素抗凝作用明显强于潘生丁（P<0.01）。

4·Hirudin has good pharmacological action, which is widely used in clinical practice.

水蛭素具有较好的药理作用，其药源丰富，在临床上应用广泛。

5·Results The drug content of prepared recombinant hirudin coated-pellets was 3.513% (w).

结果所制备的重组水蛭素肠溶包衣微丸药物含量质量分数为3.513%。

6·OBJECTIVE: To investigate the protective effect of hirudin on random skin flap congestion.

目的：观察水蛭素对大鼠随意皮瓣淤血模型成活保护作用。

7·Conclusion Damage to the thalamic tissue might be caused by thrombin and reversed by hirudin.

结论凝血酶对丘脑组织具有毒性损伤作用，但这一损伤可被水蛭素逆转。

8·OBJECTIVE Progress in different routes of administration and formulations for Hirudin are reviewed.

目的阐述水蛭素不同给药途径及相关剂型的研究进展。

9·AIM: To directed promote the antithrombotic activity of hirudin in vitro with DNA family shuffling method.

目的：运用DNA家族改组方法提高水蛭素的抗凝血酶活性。

10·As a direct thrombin inhibitor, recombinant hirudin (r-hirudin) has played an important role in clinical use.

作为直接凝血酶抑制剂，重组水蛭素在临床上的应用已越来越重要。

水蛭素

1·PurposeThe aim is to obtain recombinant hirudin gene using PCR method.

目的应用PCR方法获得水蛭素基因。

2·ConclusionThe experiments show that hirudin active factors have strong inhibition effect on S180 Tumor and CAM angiogenesis.

结论实验表明，水蛭素活性因子对S180肿瘤和CAM新生血管具有较强的抑制作用。

3·The anticoagulation effect of hirudin was better than dipyridamole (P<0.01).

水蛭素抗凝作用明显强于潘生丁（P<0.01）。

4·Objective: To investigate the anti-tumor mechanism of hirudin.

目的：探讨复方水蛭素抗肿瘤的作用机理。

5·Hirudin is an anticoagulant directly acting on thrombin. Its molecular biological and pharmacological properties, mechanism of action, current clinical researches and USES were reviewed.

水蛭素是特异的直接作用于凝血酶的抗凝剂。本文概述了其分子生物学特性、药理学特征、作用机理以及临床应用状况。