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1·Halogen atom could activate the triple bond and as the directing group, the triple bond occurs the electrophilic addition reaction.

卤原子作为保护基，代替末端炔发生碳-氢官能团化反应。

2·METHODS: Electrophilic substitution, reduction, oxidation and nucleophilic addition reaction were used in the synthesis of title compounds.

方法：通过亲核取代、还原、氧化、亲核加成等反应得到目的化合物。