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1·OBJECTIVE to study the mutation in DNA gyrase a of Escherichia coli resistante to quinolone antibiotics.

目的研究导致大肠埃希菌dna回旋酶a亚单位的基因变异耐喹诺酮类药物的机制。

2·It can affect the function of DNA gyrase in bacteria, which results in the inhibition of the duplication and transformation of DNA.

左氧氟沙星可通过作用于细菌的脱氧核糖核酸旋转酶，抑制细菌DNA的复制和转换，发挥广谱抗菌作用。